2-Chloropropionyl chloride → 6-[p-(2-Chloropropionylamino)-phenyl]-4,5-dihydropyridaz-3-one

HRID 354677

반응식

HRID 354677 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[Cl:15][CH:16]([CH3:20])[C:17](Cl)=[O:18]>C1C=CC=CC=1>[Cl:15][CH:16]([CH3:20])[C:17]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1)=[O:18]

참가 물질

4

반응물 2

HCID 1110192-Chloropropionyl chlorideHCID 6767506-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one

생성물 1

HCID 205071986-[p-(2-Chloropropionylamino)-phenyl]-4,5-dihydropyridaz-3-one수율 93%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

47.2 g (0.25 mole) of 6-(p-aminophenyl)-4,5-dihydropyridaz-3-one and 35.6 g (0.28 mole) of 2-chloropropionyl chloride in 250 ml of absolute benzene are refluxed for 2 hours. The product is filtered off at 10° C., washed first with benzene and then with water and dried under reduced pressure at 100° C. 64.8 g (93% of theory) of 6-[p-(2-chloropropionylamino)-phenyl]-4,5-dihydropyridaz-3-one are obtained as a beige solid which, after recrystallization from propanol, melts, with decomposition, at 243°-244° C.

후처리

  1. filtrationThe product is filtered off at 10° C.
  2. washwashed first with benzene
  3. dry with materialwith water and dried under reduced pressure at 100° C

출처 및 근거

ORD 기록
ord-f8980eeeaf50450da2a71f63c901e99e
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04376771

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