Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Malonate → Diethyl 2,4,5-trimethoxybenzylidenemalonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2,4,5-Trimethoxybenzaldehyde | HCID 20525 | — |
| 촉매 | Benzoic Acid | HCID 243 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Diethyl 2,4,5-trimethoxybenzylidenemalonate | HCID 13103748 | 87.8% |
반응 단계
In 80 ml of toluene is dissolved 5.9 g of 2,4,5-trimethoxybenzaldehyde, followed by addition of 4.8 g of diethyl malonate, 0.3 ml of piperidine and 0.3 g of benzoic acid. The mixture is heated under reflux for 4 hours, water being removed via an ester tube. After cooling, the solvent is distilled off under reduced pressure and the residual crystals are recovered by filtration with n-hexane to give 8.9 g (87.3%) of diethyl 2,4,5-trimethoxybenzylidenemalonate, m.p. 86°-87° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04376777 |
| 출처 데이터셋 | uspto-grants-1983_03 |
| ORD ID | ord-6f93c1aa4d9b48f088f2bd32e5d97be1 |
| 출처 메모 | uspto-grants-1983_03 |