2,3,4,5,6-Pentafluorobenzyl Alcohol → Pentafluorobenzyl fluoride

HRID 354710

반응식

HRID 354710 반응식
[F:1][C:2]1[C:7]([CH2:8]O)=[C:6]([F:10])[C:5]([F:11])=[C:4]([F:12])[C:3]=1[F:13].ClC(F)C(N(CC)CC)(F)[F:17]>C(Cl)Cl>[F:1][C:2]1[C:7]([CH2:8][F:17])=[C:6]([F:10])[C:5]([F:11])=[C:4]([F:12])[C:3]=1[F:13]

참가 물질

4

반응물 2

HCID 99232,3,4,5,6-Pentafluorobenzyl AlcoholHCID 1361842-Chloro-N,N-diethyl-1,1,2-trifluoroethan-1-amine

생성물 1

HCID 12701527Pentafluorobenzyl fluoride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

A mixture of pentafluorobenzyl alcohol (3.0 g) and dry methylene dichloride (50 ml) was cooled to a temperature of 0° C. in an ice-bath and 2-chloro-1-diethylamino-1,1,2-trifluoroethane (4.3 g) was slowly added to the cooled, stirred mixture over a period of ten minutes. After standing for a period of 18 hr at 0° C. the reaction mixture was poured into ice and the organic layer was separated and washed with IM aqueous sodium carbonate solution. The organic layer was dried over anhydrous sodium sulfate, the solvent was removed by distillation and the product was distilled under reduced pressure to give pentafluorobenzyl fluoride, b.p. 51° C. at 30 mm Hg.

후처리

  1. additionthe reaction mixture was poured into ice
  2. customthe organic layer was separated
  3. washwashed with IM aqueous sodium carbonate solution
  4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  5. customthe solvent was removed by distillation
  6. distillationthe product was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-933997dc546f4109b08b91bff02b2dcd
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04376784

연결된 노트

불러오는 중…