Formaldehyde → 2-Oxazoleethanol, 4,5-dihydro-beta-methyl-

As an example, step A was conducted by reacting 2-ethyl-2-oxazoline (4 moles) having less than 1,000 ppm of water with paraformaldehyde (1 mole) at a reaction temperature of 100° C. for approximately 5.5 hours. The excess oxazoline reactant was removed along with water as "overheads" by fractional distillation of the reaction product, leaving the 2-(α-hydroxymethylethyl)-2-oxazoline in approximately 96 percent yield. Step C was then conducted by continuously adding the 2-(α-hydroxymethylethyl)-2-oxazoline to a stirred solution of sodium hydroxide in the mono-methyl ether of triethylene glycol at a temperature of from 100°-105° C. Under these conditions, the 2-isopropenyl-2-oxazoline and water were volatilized and recovered from the overheads. The product yield was approximately 98 percent of theory.

1. customat a reaction temperature of 100° C.
2. customfor approximately 5.5 hours
3. customThe excess oxazoline reactant was removed along with water as "overheads" by fractional distillation of the reaction product

ORD 기록

ord-cc80b9ad742a44a68b171e00a1d87ef7

출처 데이터셋

uspto-grants-1983_03

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04376861