Triethylamine → 5-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

HRID 354787노트

반응식

HRID 354787 반응식
Cl[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[CH:21][C:7]1=2)=[O:5].C(N(CC)CC)C>C(O)C>[C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[CH:21][C:7]1=2)(=[O:5])[CH:3]=[CH2:2]

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 128346825-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

생성물 1

HCID 128347105-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5.0 gm (0.017 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2.0 gm (0.02 mol) of triethylamine were refluxed in 250 ml of ethanol for 30 minutes. Subsequently, the reaction mixture was evaporated in vacuo, and the residue was stirred with water. After suction-filtering and drying, 5-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one was obtained with a quantitative yield. Recrystallization from ethanol.

후처리

  1. customSubsequently, the reaction mixture was evaporated in vacuo
  2. filtrationAfter suction-filtering
  3. customdrying

출처 및 근거

ORD 기록
ord-a53088ad3e5d4f2db3eefbeecda9ce35
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377576

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