2-Chromanecarbonyl chloride → HCID 20506434, 화합물

HRID 354822노트

반응식

HRID 354822 반응식
[N:1]1([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:19][CH3:20])=[C:12]([Cl:18])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][CH2:23][CH:22]1[C:31](Cl)=[O:32]>CO>[ClH:18].[O:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][CH2:23][CH:22]1[C:31]([N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:19][CH3:20])=[C:12]([Cl:18])[CH:13]=3)[N:8]=2)[CH2:2][CH2:3]1)=[O:32]

참가 물질

4

반응물 2

HCID 27945832-Chromanecarbonyl chlorideHCID 20506419HCID 20506419, 화합물

생성물 1

HCID 20506434HCID 20506434, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 0.10 mole of 2-(piperazin-1-yl)-4-amino-6-chloro-7-methoxyquinazoline in 300 ml. of methanol is added with vigorous stirring, 0.10 mole of 2,3-dihydro-4H-benzopyran-2-carboxylic acid chloride. After the addition is complete, the mixture is stirred for three hours at room temperature and the precipitated title compound is collected by filtration.

후처리

  1. additionAfter the addition
  2. customthe precipitated title compound
  3. filtrationis collected by filtration

출처 및 근거

ORD 기록
ord-08e69cb881ff405182ce571a94b7fedf
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377581

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