3,4-Dimethoxy-2-nitrobenzoic acid → 2-Amino-3,4-dimethoxybenzoic acid
반응식
[CH3:1][O:2][C:3]1[C:4]([N+:14]([O-])=O)=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([OH:8])=[O:7].[H][H]>[OH-].[NH4+].[Pd]>[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]=1[NH2:14]참가 물질
5
실험 절차
A solution of 3,4-dimethoxy-2-nitro benzoic acid (1011 g., 4.45 moles) in 14 liters of 1.3 N ammonium hydroxide was reduced at 60 psi in presence of 60 grams of palladium on barium carbonate. Hydrogen uptake ceased after four hours. The reaction mixture was filtered through diatomaceous earth and acidified with glacial acetic acid (1.2 liters) to yield 685 grams (78%) of the anthranilic acid, M.P. 183°-184° C.
후처리
- filtrationThe reaction mixture was filtered through diatomaceous earth
출처 및 근거
- ORD 기록
- ord-9f9306c19b6b4f69a7f9343fbd0387ff
- 출처 데이터셋
- uspto-grants-1983_03
- 특허 번호
- US04377581
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