참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,1'-(Bromomethylene)bis(4-fluorobenzene) | HCID 67665 | — |
| 반응물 | Ethyl 4-hydroxypiperidine-1-carboxylate | HCID 96394 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 20506316 | HCID 20506316 | — |
반응 단계
A mixture of 21.5 parts of ethyl 4-hydroxy-1-piperidinecarboxylate, 35.2 parts of bis(4-fluorophenyl)bromomethane and 8.6 parts of potassium carbonate is stirred and heated in an oil-bath at 140° C. for 3 hours. The reaction mixture is allowed to cool to room temperature and water is added. The product is extracted with methylbenzene. The extract is washed successively with water, a diluted hydrochloric acid solution and a sodium bicarbonate solution, dried, filtered and evaporated. The forerun is distilled off (bp. till 143° C. at 0.5-1 mm. pressure), yielding ethyl 4-[bis(4-fluorophenyl)methoxy]-1-piperidinecarboxylate as an oily residue.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04377578 |
|---|
| 출처 데이터셋 | uspto-grants-1983_03 |
|---|
| ORD ID | ord-b8117dfa651246e6824c11ed9c8a7ad4 |
|---|
| 출처 메모 | uspto-grants-1983_03 |
|---|
