Potassium Carbonate → HCID 20506316, 화합물

HRID 354967

반응식

HRID 354967 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([CH:20]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)Br)=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>O>[F:13][C:14]1[CH:15]=[CH:16][C:17]([CH:20]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[O:1][CH:2]2[CH2:3][CH2:4][N:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:6][CH2:7]2)=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 676651,1'-(Bromomethylene)bis(4-fluorobenzene)HCID 96394Ethyl 4-hydroxypiperidine-1-carboxylate

생성물 1

HCID 20506316HCID 20506316, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
140 °C

실험 절차

A mixture of 21.5 parts of ethyl 4-hydroxy-1-piperidinecarboxylate, 35.2 parts of bis(4-fluorophenyl)bromomethane and 8.6 parts of potassium carbonate is stirred and heated in an oil-bath at 140° C. for 3 hours. The reaction mixture is allowed to cool to room temperature and water is added. The product is extracted with methylbenzene. The extract is washed successively with water, a diluted hydrochloric acid solution and a sodium bicarbonate solution, dried, filtered and evaporated. The forerun is distilled off (bp. till 143° C. at 0.5-1 mm. pressure), yielding ethyl 4-[bis(4-fluorophenyl)methoxy]-1-piperidinecarboxylate as an oily residue.

후처리

  1. temperatureto cool to room temperature
  2. extractionThe product is extracted with methylbenzene
  3. washThe extract is washed successively with water
  4. dry with materiala diluted hydrochloric acid solution and a sodium bicarbonate solution, dried
  5. filtrationfiltered
  6. customevaporated
  7. distillationThe forerun is distilled off (bp. till 143° C. at 0.5-1 mm. pressure)

출처 및 근거

ORD 기록
ord-b8117dfa651246e6824c11ed9c8a7ad4
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377578

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