Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl Isobutyl Ketone → Oxatomide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Bromodiphenylmethane | HCID 236603 | — |
| 반응물 | 1,3-dihydro-1-[3-(1-piperazinyl)propyl]-2H-benzimidazol-2-one | HCID 13105623 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Oxatomide | HCID 4615 | — |
반응 단계
A mixture of 13 parts of 1,3-dihydro-1-[3-(1-piperazinyl)propyl]-2H-benzimidazol-2-one, 12.4 parts of 1,1'-(bromomethylene)bis[benzene], 6.6 parts of sodium carbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with water-separator. After cooling to room temperature, water is added and the layers are separated. The organic layer is dried, filtered and evaporated. The residue is crystallized from a mixture of 2,2'-oxybispropane and a small amount of 2-propanol, yielding 1-{3-[4-(diphenylmethyl)-1-piperazinyl]propyl}-1,3-dihydro-2H-benzimidazol-2-one; mp. 153° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04377578 |
| 출처 데이터셋 | uspto-grants-1983_03 |
| ORD ID | ord-af2be737fde242559fa7e12dc79970d8 |
| 출처 메모 | uspto-grants-1983_03 |