Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 7-(2-Oxo-3-phenyl-benzimidazolin-1-yl)-enanthic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl- | HCID 84657 | — |
| 반응물 | Ethyl 7-chloroheptanoate | HCID 529988 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-(2-Oxo-3-phenyl-benzimidazolin-1-yl)-enanthic acid ethyl ester | HCID 54304288 | — |
반응 단계
The product is produced as described in example 1 from 1.9 g. of NaH (80% suspension in mineral oil), 13.2 g. of 1-phenylbenzimidazolin-2-one (produced in usual manner by subjecting N-phenyl-o-phenylenediamine to reaction with phosgene), 120 cc. of DMF, 12.1 g. of 7-chloroenanthic acid ethyl ester and 1.9 g. of NaJ. Eluant in chromatographic purification: hexane/ethylacetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04377695 |
| 출처 데이터셋 | uspto-grants-1983_03 |
| ORD ID | ord-5de6ee76530c498fbd32795bab90ea10 |
| 출처 메모 | uspto-grants-1983_03 |