Methanol → 4-Benzyl-1-[1-(4-hydroxyphenylcarbonyl)ethyl]-pyridinium bromide

HRID 355071

반응식

HRID 355071 반응식
[Br:1][CH:2]([CH3:12])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)=[O:4].[CH2:13]([C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CO>C(O)C>[Br-:1].[CH2:13]([C:20]1[CH:25]=[CH:24][N+:23]([CH:2]([C:3]([C:5]2[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=2)=[O:4])[CH3:12])=[CH:22][CH:21]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 164584-BenzylpyridineHCID 126131632-Bromo-1-(4-hydroxyphenyl)propan-1-one

생성물 1

HCID 130521134-Benzyl-1-[1-(4-hydroxyphenylcarbonyl)ethyl]-pyridinium bromide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In the condensation step, the condensation reaction between 2-bromo-4'-hydroxypropiophenone and 4-benzylpyridine is smoothly promoted in the presence of methanol and/or ethanol whereby a ketone compound of the general formula: ##STR2## i.e. 4-benzyl-1-[1-(4-hydroxyphenylcarbonyl)ethyl]-pyridinium bromide is formed in the reaction mixture. The time and the temperature adopted for the condensation reaction are usually 3-6 hours and 60°-90° C., respectively. The reaction mixture thus obtained is directly subjected as such, without isolating the above condensation product, to the catalytic reduction in the subsequent step. In this case, an additional amount of methanol and/or ethanol may be supplied to the reaction mixture.

후처리

  1. customIn the condensation step

출처 및 근거

ORD 기록
ord-22270f1a9cbb471da6a4bb893786a63d
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377691

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