Ifenprodil hydrobromide → Ifenprodil

HRID 355072

반응식

HRID 355072 반응식
[CH3:1][CH:2]([N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:14][CH2:13]1)[CH:3]([OH:11])[C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1.Br.O.N>>[CH3:1][CH:2]([N:12]1[CH2:13][CH2:14][CH:15]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:16][CH2:17]1)[CH:3]([OH:11])[C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1

참가 물질

3

반응물 2

HCID 12613162Ifenprodil hydrobromideHCID 12896473Azane;hydrate

생성물 1

HCID 3689Ifenprodil

실험 절차

In the practical preparation of the free ifenprodil, it is convenient to obtain the free ifenprodil directly from the reaction mixture, without once isolating ifenprodil hydrobromide, by adding ammonia water or a similar weakly basic substance to the filtrate from which solid matters including the catalyst have been removed, and concentrating the filtrate under reduced pressure to obtain the free compound as a residue which may, if desired, be purified by recrystallization from ethanol or isopropanol. The filtrate or mother liquor in the crystallization and/or recrystallization treatment may be subjected to silica gel column chromatography to recover a certain amount of ifenprodil. The total yields of ifenprodil can be increased by this after-treatment to about more than 90%. The free ifenprodil thus obtained may be reacted with an acid in a proper solvent to prepare an acid-addition salt with the acid.

후처리

  1. customhave been removed
  2. concentrationconcentrating the filtrate under reduced pressure
  3. customto obtain the free compound as a residue which may,
  4. custombe purified by recrystallization from ethanol or isopropanol
  5. customThe filtrate or mother liquor in the crystallization and/or recrystallization treatment
  6. customto recover a certain amount of ifenprodil

출처 및 근거

ORD 기록
ord-48259ad9489146e89d291ed00ffbe082
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04377691

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