Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-Ethyl-2-[2-(1,1-dimethylethyldimethylsilyloxy)-ethoxy]benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | (2-Bromoethoxy)-tert-butyldimethylsilane | HCID 3608067 | — |
| 반응물 | 4-Ethyl-2-hydroxybenzaldehyde | HCID 10236017 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Ethyl-2-[2-(1,1-dimethylethyldimethylsilyloxy)-ethoxy]benzaldehyde | HCID 18941597 | — |
반응 단계
This compound was prepared in a manner analogous to that of Step (b) of Example 1, using 17.0 grams (0.113 mole) of 5-ethyl-2-formylphenol, 27.7 grams (0.116 mole) of 2-(1,1-dimethylethyldimethylsilyloxy)ethyl bromide, 19.2 grams (0.139 mole) of potassium carbonate, and a catalytic amount of 18-crown-6 in 200 mL of THF. The yield of the subject compound was 12.7 grams, following purification by column chromatography on silica gel. The NMR spectrum was consistent with the proposed structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USH0001759 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-c0fbdafd837e44cd8d95fec8f23caaa1 |
| 출처 메모 | uspto-grants-1998_11 |