Acetyl bromide → 1-Acetyl-3-hydroxypyrid-2-one
반응식
[OH:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:9](Br)(=[O:11])[CH3:10]>O>[C:9]([N:3]1[CH:4]=[CH:5][CH:6]=[C:7]([OH:8])[C:2]1=[O:1])(=[O:11])[CH3:10]참가 물질
4
실험 절차
2,3-Dihydroxypyridine (5.55 g) is refluxed with acetylbromide (10 ml) overnight. The reaction mixture is allowed to cool and water (10 ml) is added. The resulting suspension is extracted with methylene chloride and the methylene chloride solution is dried over Na2SO4 and evaporated. The resultant residue is recrystallised from petroleum ether (80°-100° C.) to give 1-acetyl-3-hydroxypyrid-2-one as white crystals (2.8 g), m.p. 140°-141° C.; νmax (nujol) 1680, 3120 cm-1 ; δ(d6DMSO), 2.2 (s, 3H), 6.1 (t, 1H), 6.65 (m, 1H), 7.2 (d, 1H)
후처리
- temperatureto cool
- extractionThe resulting suspension is extracted with methylene chloride
- dry with materialthe methylene chloride solution is dried over Na2SO4
- customevaporated
- customThe resultant residue is recrystallised from petroleum ether (80°-100° C.)
출처 및 근거
- ORD 기록
- ord-09537393e73a48e4b68a6d983d0de14b
- 출처 데이터셋
- uspto-grants-1998_11
- 특허 번호
- USRE035948
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