Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide

HRID 355463노트

반응식

HRID 355463 반응식
[Br:1]Br.Cl.[C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:6])[CH3:5].CCOCC>C(Cl)Cl>[BrH:1].[Br:1][CH2:5][C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)=[O:6]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 27237674-Acetyl-4-phenylpiperidine hydrochloride

생성물 1

HCID 227417564-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide수율 196.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

8 g of bromine are added rapidly at RT to a suspension of 11.98 g of 4-acetyl-4-phenylpiperidine hydrochloride in 200 ml of DCM, and the reaction mixture is left stirring overnight at RT. It is diluted by adding 200 ml of ether, and the precipitate formed is drained and washed with ether. 17.88 g of the expected product are obtained after drying under vacuum.

후처리

  1. waitthe reaction mixture is left
  2. additionIt is diluted
  3. customthe precipitate formed
  4. washwashed with ether

출처 및 근거

ORD 기록
ord-7e9dc4906751498b9c07a52496974797
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05830906

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