Water → 4-(4-Hydroxyphenyl)-4-oxobutanoic acid
반응식
[O:1]([C:3]1[CH:15]=[CH:14][C:6]([C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])=[CH:5][CH:4]=1)C.O>II>[OH:1][C:3]1[CH:4]=[CH:5][C:6]([C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])=[CH:14][CH:15]=1참가 물질
4
반응 조건
- 온도
- 140 °C
실험 절차
The methoxy derivative, Compound 3.2 (14.54 g, 70 mmol), was dissolved in iodine free hydriodic acid (150 mL) and refluxed at 140° C. for four hours. After the resulting brown solution was cooled to room temperature, water was added and the mixture was neutralized. The aqueous phase was then washed with ether; the organic layers were combined, decolorized, dried and evaporated. The remaining residue was purified by flash silica chromatography to yield a white solid (11.93 g, 88%). 1 H NMR (CDCl3) δ8.20 (d, 2H), 7.02 (d, 2H), 3.32 (t, 2H), 2.88 (d, 2H).
후처리
- temperatureAfter the resulting brown solution was cooled to room temperature
- washThe aqueous phase was then washed with ether
- customdried
- customevaporated
- customThe remaining residue was purified by flash silica chromatography
출처 및 근거
- ORD 기록
- ord-2212cf57977845f58c8a53087ad16ca1
- 출처 데이터셋
- uspto-grants-1998_11
- 특허 번호
- US05831073
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