Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Boc-Tyr(OBn)-Ser(OBn)-CO2Me
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | O-benzyl-N-((tert-butoxy)carbonyl)-L-tyrosine | HCID 98763 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 반응물 | Ser(OBn)-CO2Me.TFA | HCID 131720920 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Boc-Tyr(OBn)-Ser(OBn)-CO2Me | HCID 131720919 | 73% |
반응 단계
To a solution of Boc-Tyr(OBn) (1.88 g, 6.50 mmol) in EtOAc (30 mL) at 0° C. was added HOBT hydrate (1.19 g, 7.80 mmol) followed by DCC (1.61 g, 7.80 mmol). A solution of Ser(OBn)-CO2Me.TFA (2.1 g, 6.50 mmol) in EtOAc (20 mL) was added followed by Et3N (1.09 mL, 7.80 mmol). The mixture was allowed to warm to room temperature and stirred overnight. The mixture was filtered, diluted with EtOAc, and washed twice with saturated aqueous NaHCO3, brine, dried over MgSO4, and concentrated. Flash chromatography (40% EtOAc/hexane) gave 2.67 g (73%) of the title compound as a white solid, mp 81°-84° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05830868 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-b912eaba23384d21b5d4e1751cf41837 |
| 출처 메모 | uspto-grants-1998_11 |