Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Chloro-4-(trifluoromethyl)benzene → N,N-Dibutyl-3-(trifluoromethyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| 반응물 | Dibutylamine | HCID 8148 | — |
| 반응물 | Lithium Bromide | HCID 82050 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N,N-Dibutyl-3-(trifluoromethyl)aniline | HCID 18943007 | — |
| 생성물 | N,N-Dibutyl-4-(trifluoromethyl)aniline | HCID 18943008 | — |
반응 단계
2.0 mmol of 4-chlorobenzotrifluoride, 2.4 mmol of di-n-butylamine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium (II) in 10 ml of toluene are reacted according to the GWI to give 4-trifluoromethylphenyl-di-n-butylamine and 3-trifluoromethylphenyl-di-n-butylamine in the ratio 7:1 in 58% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05831128 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-78047edeb39c43e8a9f0ce6ab17d7f15 |
| 출처 메모 | uspto-grants-1998_11 |