참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Ethylparaben | HCID 8434 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Butanol, 4-chloro-, 1-acetate | HCID 23399 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(4-Hydroxybutoxy)benzoic acid | HCID 15218596 | — |
반응 단계
4-Chlorobutyl acetate (276.6 g; 1.8 mol) is added to a solution of ethyl 4-hydroxybenzoate (249 g; 1.5 mol), potassium iodide (3 g) and potassium carbonate (248 g; 1.8 mol) in dimethylformamide (2 l), and the mixture is stirred at 90° C. for 11 hours. The reaction mixture is transferred into 5 l of ice water, and the resultant precipitate is filtered off with suction and washed with 4 to 5 l of ice water. The crude product is dissolved in 3 l of ethanol, potassium hydroxide (400 g) is added, and the mixture is refluxed for 3 hours. The reaction mixture is transferred into 6 l of ice water, and acidified by means of concentrated hydrochloric acid, and the precipitate is filtered off, washed with water until neutral and then dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05833880 |
|---|
| 출처 데이터셋 | uspto-grants-1998_11 |
|---|
| ORD ID | ord-003226eb613840aabf6b207b6d5d65a7 |
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| 출처 메모 | uspto-grants-1998_11 |
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