참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Ethyl 4-(1H-imidazol-1-yl)benzoate | HCID 13423940 | 56.4% |
반응 단계
Imidazole (0.816 g, 0.01 mol), ethyl 4-fluorobenzoate (2 g, 0.01 mol) and anhydrous potassium carbonate (1.43 g, 0.011 mol) was dissolved in DMSO (30 ml) and heated to 90° C. for 18 h. The solution was poured into water (50 ml), extracted with ethyl acetate (50 ml), dried (sodium sulphate), filtered and evaporated to dryness under reduced pressure. The white solid was purified by flash column chromatography (silica, diethyl ether) to afford a white solid (1.22 g, 56%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05834471 |
|---|
| 출처 데이터셋 | uspto-grants-1998_11 |
|---|
| ORD ID | ord-a3d33c33f5864abeb2dabc05dc915596 |
|---|
| 출처 메모 | uspto-grants-1998_11 |
|---|
