HCID 13837186, 화합물 → 3-(3-Ethyl-1,2,4-oxadiazol-5-yl)-9H-beta-carboline

HRID 355814노트

반응식

HRID 355814 반응식
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[C:3]([C:14](N2C=CN=C2)=O)[N:2]=1.[OH:21][NH:22][C:23](=[NH:26])[CH2:24][CH3:25]>C1(C)C=CC=CC=1.CN(C=O)C>[CH2:24]([C:23]1[N:26]=[C:14]([C:3]2[N:2]=[CH:1][C:13]3[NH:12][C:11]4[C:6]([C:5]=3[CH:4]=2)=[CH:7][CH:8]=[CH:9][CH:10]=4)[O:21][N:22]=1)[CH3:25]

참가 물질

5

반응물 2

HCID 13837186HCID 13837186, 화합물HCID 178458070HCID 178458070, 화합물

생성물 1

HCID 189407053-(3-Ethyl-1,2,4-oxadiazol-5-yl)-9H-beta-carboline수율 56.8%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 6228Dimethylformamide용매

실험 절차

To a solution of Compound 1 (1.05 g, 4 mmol) in a mixture of toluene (50 mL) and DMF (50 mL), N-hydroxypropanimidamide (0.53 g, 6 mmol) was added. The resulting mixture was heated at 140°-150° C. for 7 h, and stirring continued for 3 days at room temperture. The solvents were removed in vacuo, and the oily residue precipitated from water. The white solid (1.0 g) was dried and submitted to column chromatography on silica gel with CH2Cl2 /methanol(9:1) as eluent. This afforded the title compound (0.6 g, 56%). M.p. 146°-149° C.

후처리

  1. additionwas added
  2. temperatureThe resulting mixture was heated at 140°-150° C. for 7 h
  3. customThe solvents were removed in vacuo
  4. customthe oily residue precipitated from water
  5. dry with materialThe white solid (1.0 g) was dried

출처 및 근거

ORD 기록
ord-b526b37c7ff642cfaae9c95924f7015f
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834482

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