Nitric Acid → HCID 13037332, 화합물

HRID 355823

반응식

HRID 355823 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2].[N+:19]([O-])([OH:21])=[O:20]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][C:14]([N+:19]([O-:21])=[O:20])=[CH:13][CH:12]=3)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 105078Ethyl Beta-Carboline-3-Carboxylate

생성물 1

HCID 13037332HCID 13037332, 화합물수율 63%

실험 절차

9H-β-carboline-3-carboxylic acid ethyl ester (20 g, 833 mmol) was slowly added to concentrated nitric acid (400 mL). The reaction mixture was stirred at 70°-75° C. for 2 h. After cooling to room temperature the resulting mixture was poured onto ice (1 kg). The precipitated compound was collected, and recrystallized from pyridine (650 mL). This afforded the title compound (14.9 g, 63%). M.p. 339°-341° C.

후처리

  1. additionwas poured onto ice (1 kg)
  2. customThe precipitated compound was collected
  3. customrecrystallized from pyridine (650 mL)

출처 및 근거

ORD 기록
ord-bde2ebc93c234b76abec48393aeae3d3
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834482

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