Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → N-(2-chloro-3-hydroxybenzyl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2-Chloro-3-hydroxybenzaldehyde | HCID 593376 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-(2-chloro-3-hydroxybenzyl)piperidine | HCID 21294597 | — |
반응 단계
In a similar manner to that described in Example 17 2-chloro-3-hydroxybenzaldehyde (9 g) in absolute ethanol (60 ml) was treated with piperidine (11.7 ml) and sodium borohydride (2.2 g) to yield N-(2-chloro-3-hydroxybenzyl)piperidine. The piperidine thus prepared was reacted with 4-bromobutyronitrile to give 4-(2-chloro-3-piperidinomethylphenoxy)butyronitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04767769 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-a40479b1925649b88b9ca5b70f57c52c |
| 출처 메모 | uspto-grants-1988_08 |