Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 5-bromo-3-(pyridin-3-ylmethyl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 4-Bromophenylhydrazine hydrochloride | HCID 12157 | — |
| 반응물 | 3-(Pyridin-3-yl)propanal | HCID 11105412 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-bromo-3-(pyridin-3-ylmethyl)-1H-indole | HCID 18940837 | — |
반응 단계
A mixture of 3-pyridin-propionaldehyde (1 g; 0.0074 mol) and of 4-bromophenylhydrazin hydrochloride (1.8 g; 0.0074 mol) with acetic acid (4.44 ml) in absolute ethanol (50 ml) was refluxed for 3 hours. The reaction was then quenched with a saturated solution of aqueous sodium carbonate and the product was extracted with ethyl acetate. The organic extract was dried (MGSO4) and evaporated under vacuum. After purification by Flash Chromatography on silica gel using as eluent methylene chloride/methanol (98/2), the desired compound was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05834493 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-bfb74f571a174ea787722b430fdb89e4 |
| 출처 메모 | uspto-grants-1998_11 |