Water → 4-(3-Piperidinomethylphenylthio)butyronitrile

HRID 35605

반응식

HRID 35605 반응식
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([SH:14])[CH:11]=[CH:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:22][CH2:23][CH2:24][C:25]#[N:26].O>CN(C)C=O>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([S:14][CH2:22][CH2:23][CH2:24][C:25]#[N:26])[CH:11]=[CH:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 214124-BromobutyronitrileHCID 135055073-(Piperidin-1-ylmethyl)benzenethiol

생성물 1

HCID 212945544-(3-Piperidinomethylphenylthio)butyronitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

A stirred suspension of 3-piperidinomethylthiophenol (0.36 g) in dry dimethylformamide (4 ml) was treated with anhydrous potassium carbonate (0.5 g) and stirred for 30 minutes. 4-Bromobutyronitrile (0.18 ml) was then added to the reaction mixture with dimethylformamide (1 ml) and the resultant suspension stirred at room temperature for 48 hours. The resulting product was poured into 5 volumes of water and extracted with ethyl acetate; the extracts were washed with water, dried and evaporated to give 4-(3-piperidinomethylphenylthio)butyronitrile as an orange-red oil.

후처리

  1. extractionextracted with ethyl acetate
  2. washthe extracts were washed with water
  3. customdried
  4. customevaporated

출처 및 근거

ORD 기록
ord-f943add7633e41be847802063bf84698
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04767769

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