3-Isocyanatopyridine → 5-Trifluoromethyl-1-(3-pyridylcarbamoyl)indoline

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]=[C:8]=[O:9])[CH:2]=1.[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][CH2:16][CH2:15]2>>[F:22][C:11]([F:10])([F:21])[C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[N:17]([C:8](=[O:9])[NH:7][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[CH2:16][CH2:15]2

참가 물질

반응물 2

HCID 27604933-Isocyanatopyridine

HCID 154477895-(trifluoromethyl)-2,3-dihydro-1H-indole

생성물 1

HCID 107098435-Trifluoromethyl-1-(3-pyridylcarbamoyl)indoline

실험 절차

The title compound was prepared as in the method of (Example 2) from 3-pyridylisocyanate and 5-trifluoromethylindoline (D43) to give (E22) (0.12 g, 38%) m.p. 188°-189° C.

후처리

customto give (E22) (0.12 g, 38%) m.p. 188°-189° C.

출처 및 근거

ORD 기록: ord-9fcc26080b174b868f942b230ddbfcd1
출처 데이터셋: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05834494

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