2-Bromo-1-indanone → 2-phthalimidomethyl-8H-indeno[1,2-d]thiazole

HRID 356109

반응식

HRID 356109 반응식
Br[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=O.[C:12]1(=[O:26])[N:16]([CH2:17][C:18]([NH2:20])=[S:19])[C:15](=[O:21])[C:14]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:13]12>C(O)(C)C>[C:15]1(=[O:21])[N:16]([CH2:17][C:18]2[S:19][C:2]3[CH2:10][C:9]4[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=4[C:3]=3[N:20]=2)[C:12](=[O:26])[C:13]2=[CH:25][CH:24]=[CH:23][CH:22]=[C:14]12

참가 물질

4

반응물 2

HCID 1372032-Bromo-1-indanoneHCID 246961282-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide

생성물 1

HCID 189409622-phthalimidomethyl-8H-indeno[1,2-d]thiazole수율 50.3%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

In 100 ml of isopropanol, 1.64 g of 2-bromo-1-indanone was dissolved. Then, 2.0 g of phthalimidothioacetamide was added, followed by heating under reflux for 6 hours. The precipitate thus formed was collected by filtration and then distributed between chloroform and a saturated aqueous solution of sodium bicarbonate. The organic layer was separated, washed successively with water and a saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent was then evaporated, whereby 1.3 g of 2-phthalimidomethyl-8H-indeno[1,2-d]thiazole was obtained.

후처리

  1. temperatureby heating
  2. temperatureunder reflux for 6 hours
  3. customThe precipitate thus formed
  4. filtrationwas collected by filtration
  5. customThe organic layer was separated
  6. washwashed successively with water
  7. dry with materiala saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate
  8. customThe solvent was then evaporated

출처 및 근거

ORD 기록
ord-579db616259141bf9d77890262f0c176
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834499

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