Acetic Acid → HCID 10838316, 화합물

HRID 356256노트

반응식

HRID 356256 반응식
[CH3:1][N:2]1[C:6]2=[N:7][C:8]([S:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[CH2:18][O:19][C:20]1[CH:52]=[CH:51][C:23]([CH2:24][CH:25]2[S:29][C:28](=[O:30])[N:27](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:26]2=[O:50])=[CH:22][CH:21]=1.C(O)(=O)C>O>[CH3:1][N:2]1[C:6]2=[N:7][C:8]([S:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[CH2:18][O:19][C:20]1[CH:52]=[CH:51][C:23]([CH2:24][CH:25]2[S:29][C:28](=[O:30])[NH:27][C:26]2=[O:50])=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 10723563HCID 10723563, 화합물

생성물 1

HCID 10838316HCID 10838316, 화합물수율 97.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A procedure similar to that described in Example 12 was repeated, except that 1.58 g of 5-[4-(3-methyl-5-phenylthioimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione (prepared as described in Preparation 91) were treated with 20 ml of a 3:1 by volume mixture of acetic acid and water. After working up the product as described in Example 12, the resulting crude product was crystallized by trituration with ethyl acetate, to give 1.02 g of the title compound, melting at 166°-168° C.

후처리

  1. customthe resulting crude product was crystallized by trituration with ethyl acetate

출처 및 근거

ORD 기록
ord-6cdaf57d06f3490aaad76fd02c267844
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834501

반응 노트

불러오는 중…