Aluminium lithium hydride → 2-(2,3-dihydro-1H-indol-1-yl)ethan-1-ol

HRID 356268노트

반응식

HRID 356268 반응식
[N:1]1([CH2:10][C:11](OC)=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[N:1]1([CH2:10][CH2:11][OH:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 22199910Methyl (2,3-dihydro-1H-indol-1-yl)acetate

생성물 1

HCID 232983052-(2,3-dihydro-1H-indol-1-yl)ethan-1-ol수율 87.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A procedure similar to that described in Preparation 2 was repeated, except that 780 mg of methyl indolin-1-ylacetate (prepared as described in Preparation 8), 200 mg of lithium aluminum hydride and 12 ml of anhydrous tetrahydrofuran were used, to give 580 mg of the title compound having Rf=0.31 (on silica gel thin layer chromatography using a 2:1 by volume mixture of hexane and ethyl acetate as the developing solvent).

후처리

  1. customA procedure similar to that described in Preparation 2

출처 및 근거

ORD 기록
ord-d0f0aaf9e1494ac7af2c8f86202bfd1a
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834501

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