Oxalyl chloride → 3-(4-Nitrophenyl)propionyl chloride

HRID 356474

반응식

HRID 356474 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([OH:14])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl.CN(C=O)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([Cl:18])=[O:14])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 855263-(4-Nitrophenyl)propanoic acid

생성물 1

HCID 147973603-(4-Nitrophenyl)propionyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

3-(4-Nitrophenyl)propanoic acid prepared in Example DD (12.5 g, 64 mmol) was suspended in CH2Cl2 (300 mL) and treated with oxalyl chloride (7.4 mL, 85 mmol) and DMF (5 drops). The solution was stirred overnight at room temperature. The solution was concentrated, and the residue was dissolved in CH2Cl2 and re-concentrated. The crude product was used as is in the next step.

후처리

  1. concentrationThe solution was concentrated
  2. dissolutionthe residue was dissolved in CH2Cl2
  3. concentrationre-concentrated

출처 및 근거

ORD 기록
ord-9d995b24aa6f4bc1bc16cc3926527678
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834506

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