Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Toluene 4-thiosulfonic acid S-[2-tert-butyl-4-(2-methoxymethoxy-ethoxy)-5-methyl-phenyl] ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Methylbenzene-1-sulfonyl bromide | HCID 10130885 | — |
| 반응물 | 2-Tert-butyl-4-(2-methoxymethoxy-ethoxy)-5-methyl-benzenethiol | HCID 18798700 | — |
| 용매 | 1,1,2-Trichloroethane | HCID 6574 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Toluene 4-thiosulfonic acid S-[2-tert-butyl-4-(2-methoxymethoxy-ethoxy)-5-methyl-phenyl] ester | HCID 53987067 | — |
반응 단계
A solution of tosyl bromide (21.0 g; 89.32 mmol), 50 mL of trichloroethane and 20 mL of NEt3 was cooled to 0° C. To this solution was added slowly a solution of 12.4 mmol of 2-tert-butyl-4-(2-methoxymethoxy-ethoxy)-5-methyl-benzenethiol (prepared in Example AAAA) in 100 mL of trichloroethane. After 13 hours, the reaction mixture was diluted with EtOAc and washed with brine. The product was purified by flash silica gel chromatography, eluting with EtOAc:hexane (5:95, then switching to 3:7).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05834506 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-295045b58ba843feb787f80e37f1aa1e |
| 출처 메모 | uspto-grants-1998_11 |