Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 3beta-Hydroxymethoxy-androsten-17-one acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Dehydroepiandrosterone | HCID 5881 | — |
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Chloromethyl acetate | HCID 69366 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3beta-Hydroxymethoxy-androsten-17-one acetate | HCID 131720942 | — |
반응 단계
To a solution of dehydroepiandrosterone (2.88 g, 10 mmol) in THF (100 mL) is added sodium hydride (11 mmol, 60% in oil) at room temperature under an argon atmosphere. When all the sodium hydride has reacted, chloromethyl acetate (prepared from acetyl chloride and formaldehyde (or derivative) using ZnCl2 as catalyst) is added and the mixture is heated for a few hours. After cooling, the mixture is poured into water and extracted with ethyl acetate. The organic phase is then washed with water, dried, filtered and evaporated to dryness to give the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05837700 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-16c78ee6ebb64ca5bf1cc7df87333e49 |
| 출처 메모 | uspto-grants-1998_11 |