Tributyltin Chloride → 1H-Pyrrole-1-carboxylic acid, 2-(tributylstannyl)-, 1,1-dimethylethyl ester

HRID 356604

반응식

HRID 356604 반응식
[C:1]([O:5][C:6]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[Sn:13]([CH2:22][CH2:23][CH2:24][CH3:25])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:14][CH2:15][CH2:16][CH3:17])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Li+].CC([N-]C(C)C)C.C(OC(N1C=CC=C1)=O)(C)(C)C.C([Sn](Cl)(CCCC)CCCC)CCC>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[Sn:13]([CH2:14][CH2:15][CH2:16][CH3:17])([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:18][CH2:19][CH2:20][CH3:21])=[O:7])([CH3:3])([CH3:4])[CH3:2]

참가 물질

5

반응물 3

HCID 15096Tributyltin ChlorideHCID 643494tert-butyl 1H-pyrrole-1-carboxylateHCID 86753332HCID 86753332, 화합물

생성물 1

HCID 113630591H-Pyrrole-1-carboxylic acid, 2-(tributylstannyl)-, 1,1-dimethylethyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

(1-(t-Butoxycarbonyl)pyrrol-2-yl)tributyltin LDA in dry THF (1.2M, 0.83 mL) was slowly added to a cooled (-78° C.) solution of 1-(t-butoxycarbonyl)pyrrole (0.67 g) in dry THF (5 mL). After stirring for 3 h, tributyltin chloride (0.65 g) was slowly added, and the mixture was allowed to warm to room temperature overnight. The solvent was removed to provide (1-(t-butoxycarbonyl)pyrrol-2-yl)tributyltin, suitable for use in the next reaction.

후처리

  1. customThe solvent was removed

출처 및 근거

ORD 기록
ord-f8fd33df5b2b4687b7292d5d66b34ca6
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05837704

연결된 노트

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