4-Chloroaniline → 4-Chloro-N-[(1H-imidazol-2-yl)methyl]aniline

반응식

[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH:14]=O>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:14][C:10]2[NH:9][CH:13]=[CH:12][N:11]=2)=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 78124-Chloroaniline

HCID 249551H-imidazole-2-carbaldehyde

생성물 1

HCID 108460134-Chloro-N-[(1H-imidazol-2-yl)methyl]aniline수율 72%

실험 절차

The title compound was prepared from 4-chloroaniline and 2-imidazole-carboxaldehyde by the same procedure as described in Example 24, part A. The residue was crystallized from ethyl acetate to afford the title compound (1.56 g, 72%) as an off white solid.

후처리

customThe residue was crystallized from ethyl acetate

출처 및 근거

ORD 기록: ord-686b47919246456c9585f37f18fabb82
출처 데이터셋: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05837702

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