Behenyl Alcohol → Docosyl chlorooxalate

HRID 356695노트

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HRID 356695 반응식
[CH2:1]([OH:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[C:24](Cl)(=[O:28])[C:25]([Cl:27])=[O:26]>>[C:25]([Cl:27])(=[O:26])[C:24]([O:23][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:28]

참가 물질

3

반응물 2

HCID 12620Behenyl AlcoholHCID 65578Oxalyl chloride2회

생성물 1

HCID 57126642Docosyl chlorooxalate수율 92.5%

실험 절차

In this example the product was prepared in two synthetic steps. In the first step docosanol was reacted with 50% molar excess of oxalyl chloride. Upon completion of the reaction the excess oxalyl chloride was stripped from the product at reduced pressure to produce docosyl chlorooxalate having an assay of 91.4% and in a corrected yield of 92.5%. In the second step docosyl chlorooxalate was reacted with 2,5-dimethyl-2,5-dihydroperoxyhexane, in the presence of pyridine, to yield the product:

출처 및 근거

ORD 기록
ord-ae93638d787b499993273924d487cb7f
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05837782

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