Water → 5-Chloro-6-hydroxy-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline

HRID 35675노트

반응식

HRID 35675 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12](=[O:15])[CH2:13][CH3:14])[CH2:7][CH2:6][C:5]2=[O:16].[Cl:17]N1C(=O)CCC1=O.O>CN(C)C=O>[Cl:17][C:3]1[C:2]([OH:1])=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5](=[O:16])[CH2:6][CH2:7][N:8]2[C:12](=[O:15])[CH2:13][CH3:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 212948076-Hydroxy-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline

생성물 1

HCID 212947795-Chloro-6-hydroxy-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline수율 91.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 6-hydroxy-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (1.643 g) and N-chlorosuccinimide (1.068 g) in N,N-dimethylformamide (10 ml) was stirred at room temperature for 18 hours, poured into water, and extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate, and evaporated in vacuo. The residual solid was recrystallized from chloroform to give 5-chloro-6-hydroxy-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (1.74 g).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo
  5. customThe residual solid was recrystallized from chloroform

출처 및 근거

ORD 기록
ord-fa1b9d71ea7541dbb5c0c0561a49f4de
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04767780

반응 노트

불러오는 중…