6-Nitro-4-oxo-1-propionyl1,2,3,4-tetrahydroquinoline → 6-Amino-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline
반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]([C:14](=[O:17])[CH2:15][CH3:16])[CH2:9][CH2:8][C:7]2=[O:18])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]([C:14](=[O:17])[CH2:15][CH3:16])[CH2:9][CH2:8][C:7]2=[O:18]참가 물질
4
실험 절차
A solution of 6-nitro-4-oxo-1-propionyl1,2,3,4-tetrahydroquinoline (6.076 g) in methanol (60 ml) was hydrogenated over 5% palladium on carbon (0.5 g) under atmospheric pressure at ambient temperature. After the theoretical amount of hydrogen gas was absorbed, the catalyst was filtered off and the filtrate was evaporated in vacuo. The residual solid was washed with diethyl ether and dried to give 6amino-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (4.815 g).
후처리
- customAfter the theoretical amount of hydrogen gas was absorbed
- filtrationthe catalyst was filtered off
- customthe filtrate was evaporated in vacuo
- washThe residual solid was washed with diethyl ether
- customdried
출처 및 근거
- ORD 기록
- ord-0af32720cf964cb6b5c302da4faf5314
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04767780
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