Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Ibuprofen methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Dexibuprofen | HCID 39912 | — |
| 생성물 | Ibuprofen methyl ester | HCID 109101 | — |
반응 단계
S-(+)-ibuprofen (5.0 g; 0.024 mole) was shed into methanol (35 ml), concentrated sulfuric acid (1 ml) was added and the reaction mixture was heated for 3 hours at the reflux temperature of the reaction mixture. Then it was evaporated in vacuo at the temperature of 30° C. to dryness. S-(+)-ibuprofen methyl ester (5.1 g) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05840714 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-df4c121a7edc488eacf23da102b372c5 |
| 출처 메모 | uspto-grants-1998_11 |