Ethanol → 2-(2-Phenylethyl)malonic acid

HRID 356874

반응식

HRID 356874 반응식
[CH2:1]([CH2:8][CH:9]([C:15]([O:17]CC)=[O:16])[C:10]([O:12]CC)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)C.[OH-].[K+]>O>[CH2:1]([CH2:8][CH:9]([C:15]([OH:17])=[O:16])[C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 811191,3-Diethyl 2-(2-phenylethyl)propanedioate

생성물 1

HCID 1012342-(2-Phenylethyl)malonic acid수율 83.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The diethyl benzylmethylmalonate (75 g) was combined with 300 ml of ethanol and a solution of 100 g potassium hydroxide in 300 ml of water and heated to a gentle reflux for 5 hours. After cooling, the mixture was extracted with diethyl ether (2×300 ml). The aqueous phase was then acidified with 120 ml concentrated hydrochloric acid, and extracted with diethyl ether (3×300 ml). The combined organic extracts were dried over magnesium sulfate, filtered and concentrated to yield 49.2 g of benzylmethylmalonic acid as a yellow solid (83% yield).

후처리

  1. temperaturea gentle reflux for 5 hours
  2. temperatureAfter cooling
  3. extractionthe mixture was extracted with diethyl ether (2×300 ml)
  4. extractionextracted with diethyl ether (3×300 ml)
  5. dry with materialThe combined organic extracts were dried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-64f66f15122b4aee823bd86f5b9c991e
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840729

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