3-Amino-4-chloropyridine → Benzamide,n-(4-chloro-3-pyridinyl)-3-(cyclopentyloxy)-4-methoxy-

HRID 356886

반응식

HRID 356886 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH2:8].[CH:9]1([O:14][C:15]2[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=2[O:24][CH3:25])[C:18](Cl)=[O:19])[CH2:13][CH2:12][CH2:11][CH2:10]1>N1C=CC=CC=1.C(OCC)C>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][C:18](=[O:19])[C:17]1[CH:21]=[CH:22][C:23]([O:24][CH3:25])=[C:15]([O:14][CH:9]2[CH2:10][CH2:11][CH2:12][CH2:13]2)[CH:16]=1

참가 물질

5

반응물 2

HCID 5819323-Amino-4-chloropyridineHCID 27946003-(Cyclopentyloxy)-4-methoxybenzoyl chloride

생성물 1

HCID 10337712Benzamide,n-(4-chloro-3-pyridinyl)-3-(cyclopentyloxy)-4-methoxy-수율 59.2%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 3283Diethyl Ether용매

실험 절차

A stirred solution of 4-chloropyrid-3-ylamine (1.94 g) and 3-cyclopentyloxy-4-methoxybenzoyl chloride (3.85 g) in pyridine (50 mL) is heated at 80° C. for 7 hours and then it is allowed to stand overnight. The reaction mixture is evaporated, to give a brown oil, which is subjected to mplc on silica gel, using diethyl ether as eluent, to give N-(4-chloropyrid-3-yl)-3-cyclopentyloxy-4-methoxybenzamide (3.1 g), m.p. 130°-132° C.

후처리

  1. customThe reaction mixture is evaporated
  2. customto give a brown oil, which

출처 및 근거

ORD 기록
ord-9847f5fedba34077bda6c5fcae598803
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840724

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