Triethylamine → HCID 21187839, 화합물

HRID 356902

반응식

HRID 356902 반응식
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:11]=[CH:12][C:13]=2[O:14][CH3:15])[NH2:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:25]=1[N:31]=[C:32]=[O:33]>ClCCl>[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:25]=1[NH:31][C:32]([NH:10][C:9]1[CH:11]=[CH:12][C:13]([O:14][CH3:15])=[C:7]([O:6][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)[CH:8]=1)=[O:33]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 6045371,3-Dichloro-2-isocyanatobenzeneHCID 27793343-(Cyclopentyloxy)-4-methoxyaniline

생성물 1

HCID 21187839HCID 21187839, 화합물수율 56%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A stirred solution of 3-cyclopentyloxy-4-methoxyaniline (1 g) and triethylamine (0.69 mL) in dry dichloromethane (20 mL) is treated dropwise at 0°-5° C. with a solution of 2,6-dichlorophenyl isocyanate (0.9 g) in dry dichloromethane (10 mL). The resulting mixture is stirred for 30 minutes at this temperature and then for 6 hours at room temperature. The precipitate which forms is collected and stirred with isopropanol (50 mL), with ice cooling. The resulting solid is collected and dried, to give N-(2,6-dichlorophenyl)-N'-(3-cyclopentyloxy-4-methoxyphenyl)urea (1.06 g), m.p. 203°-204° C. [Elemental analysis: C,57.2; H,5.0; N,7.0; Cl,18.2%; calculated: C,57.7; H,5.1; N,7.1; Cl,18.0%].

후처리

  1. waitfor 6 hours at room temperature
  2. customThe precipitate which forms is collected
  3. stirringstirred with isopropanol (50 mL), with ice cooling
  4. customThe resulting solid is collected
  5. customdried

출처 및 근거

ORD 기록
ord-b8fe25528be34bf69fb2ac3fb8c32d8c
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840724

연결된 노트

불러오는 중…