Ammonia → 3-Cyclopentyloxy-4-methoxybenzamide

반응식

[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[C:10](Cl)=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:18]>>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[C:10]([NH2:18])=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 222Ammonia

HCID 27946003-(Cyclopentyloxy)-4-methoxybenzoyl chloride

생성물 1

HCID 27793303-Cyclopentyloxy-4-methoxybenzamide

실험 절차

Vigorously stirred aqueous ammonia solution (70 mL; 32% w/w) is treated dropwise with warm molten 3-cyclopentyloxy-4-methoxybenzoyl chloride (25.7 g) during a period of 20 minutes, keeping the temperature below 20° C. Stirring is continued at 20° C. for 2 hours, and then the suspension is filtered. The resulting solid is washed with water until free of ammonia, and is then dried under vacuum at 40°-45° C., to give 3-cyclopentyloxy-4-methoxy-benzamide (21.78 g), in the form of a buff solid.

후처리

customthe temperature below 20° C
filtrationthe suspension is filtered
washThe resulting solid is washed with water until free of ammonia
customis then dried under vacuum at 40°-45° C.

출처 및 근거

ORD 기록: ord-65249cee1a134c12b4e7c206c2206b12
출처 데이터셋: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05840724

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