Water → Methyl 3-isopropoxy-4-nitrobenzoate

HRID 356971

반응식

HRID 356971 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[C:5]([O:7][CH3:8])=[O:6].C(=O)([O-])[O-].[K+].[K+].Br[CH:22]([CH3:24])[CH3:23].O>CN(C)C=O>[CH:22]([O:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[C:5]([O:7][CH3:8])=[O:6])([CH3:24])[CH3:23]

참가 물질

6

반응물 4

HCID 962WaterHCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 294866Methyl 3-hydroxy-4-nitrobenzoate

생성물 1

HCID 21187964Methyl 3-isopropoxy-4-nitrobenzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of methyl 3-hydroxy-4-nitrobenzoate (5.9 g) in dimethylformamide (40 mL) is treated with potassium carbonate (6.2 g) and 2-bromopropane (3.7 g), and the stirred solution is heated at 60°-65° C. for 4 hours. After cooling, water (100 mL) is added and the solution is extracted with toluene (2×100 mL) The combined organic extracts are dried over magnesium sulfate and evaporated in vacuo, to give methyl 3-isopropoxy-4-nitrobenzoate, in the form of a pale yellow solid (5.9 g), m.p. 46°-48° C.

후처리

  1. temperaturethe stirred solution is heated at 60°-65° C. for 4 hours
  2. temperatureAfter cooling
  3. extractionthe solution is extracted with toluene (2×100 mL) The combined organic extracts
  4. dry with materialare dried over magnesium sulfate
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-90074f4ec8f14455b9178da867a3572d
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840724

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