Triethylamine → Imidazo[1,2-a]pyridine,5-[(4-chlorobutyl)thio]-

HRID 357000

반응식

HRID 357000 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][Cl:6].[SH:7][C:8]1[N:13]2[CH:14]=[CH:15][N:16]=[C:12]2[CH:11]=[CH:10][CH:9]=1.C(N(CC)CC)C>C(O)C>[Cl:6][CH2:5][CH2:4][CH2:3][CH2:2][S:7][C:8]1[N:13]2[CH:14]=[CH:15][N:16]=[C:12]2[CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 813641-Bromo-4-chlorobutaneHCID 178418687HCID 178418687, 화합물

생성물 1

HCID 18936641Imidazo[1,2-a]pyridine,5-[(4-chlorobutyl)thio]-

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In a nitrogen atmosphere, 8.87 ml (77 mmol) of 1-bromo-4-chlorobutane was added to a solution of 10.51 g (70 mmol) of 5-mercaptoimidazo[1,2-a]pyridine and 10.73 ml (77 mmol) of triethylamine in 150 ml of ethanol was added, followed by stirring at room temperature for 16 hours. After the solvent was distilled off, the residue was dissolved in dichloromethane. This solution was washed with saturated aqueous sodium hydrogen carbonate and dried, after which the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate) to yield 12.93 g (76.7%, light brown oily substance) of the desired product.

후처리

  1. additionwas added
  2. distillationAfter the solvent was distilled off
  3. dissolutionthe residue was dissolved in dichloromethane
  4. washThis solution was washed with saturated aqueous sodium hydrogen carbonate
  5. customdried
  6. distillationafter which the solvent was distilled off
  7. customThe residue was purified by column chromatography (eluent: ethyl acetate)

출처 및 근거

ORD 기록
ord-afc7370ad75e49a9ac250316b96f5076
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840732

연결된 노트

불러오는 중…