Triethylamine → 5-(4-Methanesulfonyloxybutylthio)-imidazo[1,2-c]pyrimidine

HRID 357025노트

반응식

HRID 357025 반응식
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][N:8]=1.C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>>[CH3:23][S:24]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][N:8]=1)(=[O:26])=[O:25]

참가 물질

4

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 189368825-(4-Hydroxybutylthio)imidazo[1,2-c]pyrimidine

생성물 1

HCID 189368805-(4-Methanesulfonyloxybutylthio)-imidazo[1,2-c]pyrimidine

실험 절차

Using 2.23 g (10 mmol) of 5-(4-hydroxybutylthio) imidazo[1,2-c]pyrimidine, 1.53 ml (11 mmol) of triethylamine and 0.85 ml (11 mmol) of methanesulfonyl chloride, the same procedure as in Reference Example 8 was followed, to yield 5-(4-methanesulfonyloxybutylthio)-imidazo[1,2-c]pyrimidine.

출처 및 근거

ORD 기록
ord-9e83855df2c74aa895cd3dcd870a5d9d
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840732

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