참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | 2-Propen-1-ol, 3-(3,4-dichlorophenyl)- | HCID 53709191 | — |
| 촉매 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(3,4-Dichlorophenyl)-2-propene-1-ol acetate | HCID 53852844 | 97% |
반응 단계
Treat a solution of the product of step 2 (13.2 g, 65 mmol) in CH2Cl2 (250 mL) at 0° C. with pyridine (7.89 mL, 97.5 mmol, 1.5 eq) and dimethylaminopyridine (397 mg, 3.25 0.05 eq), followed by CH3COCl (6.48 mL, 74.75 mmol, 1.15 eq). Allow the mixture to warm to 23° C., pour into 1M HCl (100 mL) and wash the resulting organic layer again with 1 M HCl (100 mL), followed by water (5×100 mL; pH=6.5-7). Dry the organic layer (Na2SO4) and concentrate to obtain 15.4 g (62.9 mmol, 97%) of 3-(3,4-dichlorophenyl)-2-propene-1-ol acetate as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05840725 |
|---|
| 출처 데이터셋 | uspto-grants-1998_11 |
|---|
| ORD ID | ord-596ba5ac38d843dda8fd994e96809546 |
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| 출처 메모 | uspto-grants-1998_11 |
|---|
