Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Cni H1594
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 3'-Aminoacetophenone | HCID 7417 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 2-Amino-4-chloro-6-methylpyrimidine | HCID 21810 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Cni H1594 | HCID 133110 | 78.5% |
반응 단계
Compound No. 15 (CNI-1594): A suspension of m-aminoacetophenone (2.7 g) and 2-amino-4-chloro-6-methyl-pyrimidine (2.87 g) in 40 mL water was treated with 1.7 mL concentrated HCl and heated at reflux for 1 hour. Addition of 40 mL 1N KOH gave a light buff solid, which was filtered out and dried to give 3.8 g 4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine, mp 196°-98° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05840893 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-97ca793596bb409cac5332c8f4ef0d63 |
| 출처 메모 | uspto-grants-1998_11 |