Vinyl propanoate → (R)-2-bromo-1-(3-chlorophenyl)ethanol

HRID 357725

반응식

HRID 357725 반응식
[Br:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=1)[OH:4].C(OC(=O)CC)(=O)CC.C(OC=C)(=O)CC>COC(C)(C)C>[Br:1][CH2:2][C@@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=1)[OH:4]

참가 물질

5

반응물 3

HCID 7750Vinyl propanoateHCID 31263Propionic anhydrideHCID 99646942-Bromo-1-(3-chlorophenyl)ethanol

생성물 1

HCID 11075396(R)-2-bromo-1-(3-chlorophenyl)ethanol

시약·촉매·용매 1

HCID 15413tert-Butyl methyl ether용매

실험 절차

To a mixture of 100 mg (0.4 mmol) of 2-bromo-1-(3-chlorophenyl)ethanol, 10 mg of Lipase QL (Meito Sangyo Co., Ltd.) and 39 mg (0.3 mmol) of propionic anhydride or 30 mg (0.36 mmol) of vinyl propionate as an acylating agent was added t-butyl methyl ether to make the total volume to 1 ml. These reaction mixtures were respectively allowed to undergo reaction at a temperature of 35° C. for 22 hours. The results are set forth in Table 4.

후처리

  1. customThese reaction mixtures
  2. customreaction at a temperature of 35° C. for 22 hours

출처 및 근거

ORD 기록
ord-dacd54e292724f31a131447cf2e7c5c5
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05841001

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