2-chlorothiophene-3-carboxylic Acid → 5-Bromo-2-chlorothiophene-3-carboxylic acid

HRID 357797노트

반응식

HRID 357797 반응식
[Cl:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([OH:9])=[O:8].C1C=C[NH+]=CC=1.[Br:16][Br-]Br>C(O)(=O)C>[Br:16][C:4]1[S:3][C:2]([Cl:1])=[C:6]([C:7]([OH:9])=[O:8])[CH:5]=1

참가 물질

3

반응물 1

HCID 36627282-chlorothiophene-3-carboxylic Acid

생성물 1

HCID 223971905-Bromo-2-chlorothiophene-3-carboxylic acid수율 77.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
40 °C

실험 절차

A mixture of 2-chloro-3-thiophenecarboxylic acid (2.44 g), pyridinium bromide perbromide (5.33 g) and acetic acid (15 ml) was stirred at 40° C. for 4 hours and poured into ice-water. Precipitated crystals were collected by filtration, dissolved in ethyl acetate and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to give 5-bromo-2-chloro-3-thiophenecarboxylic acid (2.81 g) as crystals.

후처리

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. dissolutiondissolved in ethyl acetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationThe solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-572152529d804ea3aea13e865119883c
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840917

반응 노트

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